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Raloxifene also may increase your risk of blood clots. Taking this drug can reduce the risk of some types of breast cancer. Raloxifene (Evista) mimics estrogen's beneficial effects on bone density in postmenopausal women, without some of the risks associated with estrogen. Therefore, estrogen is typically used for bone health in younger women or in women whose menopausal symptoms also require treatment. However, estrogen therapy can increase the risk of breast cancer and blood clots, which can cause strokes. Hormone-related therapyĮstrogen, especially when started soon after menopause, can help maintain bone density. Recent research indicates there could be a high risk of spinal column fractures after stopping the drug. ![]() If you take denosumab, you might need to continue to do so indefinitely. Similar to bisphosphonates, denosumab has the same rare complication of causing breaks or cracks in the middle of the thighbone and osteonecrosis of the jaw. SPINE PROFESSIONAL AND ESSENTIAL LICENSE KEY SKINDenosumab is delivered via a shot under the skin every six months. DenosumabĬompared with bisphosphonates, denosumab (Prolia, Xgeva) produces similar or better bone density results and reduces the chance of all types of fractures. ![]() This can occur after an invasive dental procedure, such as removing a tooth. A second rare complication is delayed healing of the jawbone (osteonecrosis of the jaw). SPINE PROFESSIONAL AND ESSENTIAL LICENSE KEY CRACKIntravenous forms of bisphosphonates don't cause stomach upset but can cause fever, headache and muscle aches.Ī very rare complication of bisphosphonates is a break or crack in the middle of the thighbone. These are less likely to occur if the medicine is taken properly. Side effects include nausea, abdominal pain and heartburn-like symptoms. Bisphosphonatesįor both men and women at increased risk of fracture, the most widely prescribed osteoporosis medications are bisphosphonates. If your risk isn't high, treatment might not include medication and might focus instead on modifying risk factors for bone loss and falls. Treatment recommendations are often based on an estimate of your risk of breaking a bone in the next 10 years using information such as the bone density test. ![]()
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